The Active Ingredients In ClearifiRx Prescription Hyperpigmentation Creams

The Active Ingredients In ClearifiRx Prescription Hyperpigmentation Creams

When you choose ClearifiRx, our promise to you is only to use ingredients that have been scientifically proven to help improve your condition. Our science-backed ingredients are custom-blended for your skin in order to offer the best results for treating your hyperpigmentation.

1. Hydroquinone

Type: Topical Medication

Used to treat: Dark spots caused by freckles, age spots, and melasma

How it works: As a depigmenting agent, hydroquinone interrupts the formation and synthesis of melanin to help lighten the skin.

Brief Description

Hydroquinone is a skin lightening or skin bleaching topical application. It is useful in treating dark spots or different types of hyperpigmentation. Hydroquinone has been used for decades and is one of the most studied pharmaceutical agents on the market. As an FDA-approved medication, numerous clinical studies have proven both its safety and efficacy. While you can buy hydroquinone over the counter, it yields the best results when prescribed as a custom-formulation based on your specific needs.

Scientific Studies

Side Effects

Numerous studies have found no notable side effects caused by using hydroquinone. Any side effects from using a topical preparation combining hydroquinone with other medications may be caused by the other ingredients. The FDA has identified one side effect called ochronosis, a bluish-black pigmentation with papules. There is one report of this side effect for every 300 million units of hydroquinone sold in the United States.

Mild side-effects are normal and mean the medication is working. Our doctors are always on hand to monitor your progress, track any side effects and assist with any questions you may have.

This is not a complete list of side effects. Since drugs affect each person differently, other side effects may occur. Before use, we recommend discussing possible side effects with a healthcare provider who knows your medical history. You may also report side effects to your local poison control center or call the FDA at 1-800-FDA-1088.

2. Adapalene

Type: Topical Medication

Used to treat: Acne, pimples, hyperpigmentation, melasma

How it works: Adapalene slows down the melanin-forming process, encourages collagen production and dermis thickening, increases the rate of skin cell turnover and exfoliation, and speeds up the removal of pigmented skin cells.

Brief Description

Adapalene is a retinoid, a biologically active form of Vitamin A. It is primarily used to treat acne and acne-induced post-inflammatory hyperpigmentation. Due to its action on cellular growth and reducing inflammation, the medication is ideal for managing multiple skin conditions. Adapalene can be used as a skin lightening medication, an anti inflammatory agent, and a skin exfoliation catalyst. Adapalene has also been shown to increase the penetration and efficacy of other topical skin medication ingredients.

Scientific Studies

  • Study 1: Long-term safety and efficacy study of Adapalene 0.3% gel.
    “The efficacy and safety of Adapalene 0.1% gel in the treatment of acne vulgaris has been demonstrated in multiple controlled clinical trials. A higher concentration formulation, Adapalene 0.3% gel, has been developed to provide a broader range of treatment options for acne management.”
  • Study 2: A review of the use of Adapalene for the treatment of acne vulgaris
    “Over the past five years, numerous clinical trials have been conducted on comparing the efficacy and tolerability of Adapalene and tretinoin in the treatment of acne vulgaris. These clinical studies demonstrate that adapalene treatment is a good choice for topical treatment of acne vulgaris with fewer side effects and high efficacy.”

Side Effects

The most common side effects of Adapalene are a brief sensation of stinging or warmth, dry skin, redness, and peeling during the first two to four weeks of use. These side effects are generally considered mild, with a reduction in symptoms occurring over time. Adapalene has no known severe side effects or allergic reactions. In general, Adapalene is regarded as a very tolerable retinoid medication.

Mild side-effects are normal and mean the medication is working. Our doctors are always on hand to monitor your progress, track any side effects and assist with any questions you may have.

This is not a complete list of side effects. Since drugs affect each person differently, other side effects may occur. Before use, we recommend discussing possible side effects with a healthcare provider who knows your medical history. You may also report side effects to your local poison control center or call the FDA at 1-800-FDA-1088.

3. Azelaic Acid

Type: Topical Medication

Used to treat: Inflammation, hyperpigmentation, acne bacteria

How it works: Azelaic acid reduces inflammation, slows down and reverses hyperpigmentation, and treats bacterial acne pimples.

Brief Description

Azelaic acid is a naturally occurring saturated dicarboxylic acid found in grains like wheat, barley, and rye. It is ideal for treating skin conditions owing to its exceptional anti-inflammatory and antimicrobial properties. Additionally, azelaic acid exhibits tyrosinase inhibition properties. This effect reduces the production and growth of melanocytes, resulting in lighter skin. At the same time, the acid also encourages global cellular turnover at the application point, leading to faster healing and reduced acne scarring.

Scientific Studies

Side Effects

Azelaic acid common side effects include a burning or tingling sensation, skin peeling, and redness or dryness at the application site. Less common side effects include irritation, swelling, blistering, flaking, fever, joint pain, and difficulty breathing. Some of these less common side effects may be classed as allergic reactions, so care must be taken when applying azelaic acid medications for the first time. Azelaic acid is also known to thin the skin, which may expose your skin to sunburn and harmful UV ray effects like sun damage and sunspots.

Mild side-effects are normal and mean the medication is working. Our doctors are always on hand to monitor your progress, track any side effects and assist with any questions you may have.

This is not a complete list of side effects. Since drugs affect each person differently, other side effects may occur. Before use, we recommend discussing possible side effects with a healthcare provider who knows your medical history. You may also report side effects to your local poison control center or call the FDA at 1-800-FDA-1088.

4. Desonide

Type: Topical Medication

Used to treat: Mild inflammation, melasma, sun spots, post-inflammatory hyperpigmentation

How it works: Prevents the release of substances in the skin that cause inflammation and lead to skin darkening.

Brief Description

Desonide is a mild corticosteroid used to relieve inflammation of the skin. Inflammation can be caused by sun exposure, wind exposure, or exposure to other harsh elements or substances. Desonide reduces inflammation to lessen redness, swelling, itching, or any other discomfort you may be feeling. Due to its anti-inflammatory properties, Desonide has been proven to be clinically useful in reducing post-inflammatory conditions such as melasma, hyperpigmentation, and sun, liver, and other dark spots.

Scientific Studies

Side Effects

The most common Desonide side effects are skin redness, burning, stinging, irritation, worsening of the condition, a rash, skin peeling, swelling, itching, dryness, and development of scales. These side effects are typically mild and short-lived, going away after some time. Serious Desonide side effects include infection accompanied by a fever, cough, and sore throat. Although unlikely, you may have a mild to severe allergic reaction to the drug presenting as a heat rash with painful red bumps and blisters and swelling of your face, tongue, or lips. Side effects beyond four weeks of continued use are not known.

Mild side-effects are normal and mean the medication is working. Our doctors are always on hand to monitor your progress, track any side effects and assist with any questions you may have.

This is not a complete list of side effects. Since drugs affect each person differently, other side effects may occur. Before use, we recommend discussing possible side effects with a healthcare provider who knows your medical history. You may also report side effects to your local poison control center or call the FDA at 1-800-FDA-1088.

5. Arbutin (Ar)

Type: Topical Medication

Used to treat: Hyperpigmentation

How it works: Arbutin lightens the skin by safely inhibiting the cellular enzymes in skin cells that create pigment.

Brief Description

Arbutin is a naturally occurring skin lightening and depigmenting agent commonly extracted from the dried leaves of the bearberry plant. It is one of the most prescribed skin-lightening medications in the world. Traces of Arbutin can be found in several other plant species, including wheat, pear, blueberry, and cranberry. Arbutin acts by inhibiting tyrosinase, effectively preventing the formation of melanin with few signs of cytotoxicity. Arbutin is safe to use over extended periods.

Scientific Studies

Side Effects

With few controlled clinical trials or studies of arbutin, side effects are not well understood. However, the widespread use of arbutin as a skin-lightening agent with few reported side effects indicates it is safe to use.

Mild side-effects are normal and mean the medication is working. Our doctors are always on hand to monitor your progress, track any side effects and assist with any questions you may have.

This is not a complete list of side effects. Since drugs affect each person differently, other side effects may occur. Before use, we recommend discussing possible side effects with a healthcare provider who knows your medical history. You may also report side effects to your local poison control center or call the FDA at 1-800-FDA-1088.

6. Lipoic Acid (LA)

Type: Topical Medication

Used to treat: Hyperpigmentation, fine lines, wrinkles, shrink skin pores

How it works: As a powerful antioxidant, lipoic acid reduces the free radicals in your skin, reducing creasing and wrinkles and giving your skin a healthy glow.

Brief Description

Lipoic acid or alpha lipoic acid (ALA) naturally occurs within mitochondria cells. As a potent antioxidant, its primary role is to eliminate free radicals and maintain cellular health. ALA is soluble in both water and oil, a property that enables easy absorption when applied to the skin. As a skin treatment, ALA is absorbed through the epidermis into the dermis, delivering antioxidative effects to the skin cells. Quick absorption can reduce hyperpigmentation, skin wrinkles, and skin discoloration.

Scientific Studies

Side Effects

Side effects associated with topical applications of lipoic acid appear to be mild and infrequent. This may be due to a lack of extensive clinical studies on the long-term effects of applying lipoic acid. Lipoic acid is, however, currently considered a safe skin treatment medication.

Mild side-effects are normal and mean the medication is working. Our doctors are always on hand to monitor your progress, track any side effects and assist with any questions you may have.

This is not a complete list of side effects. Since drugs affect each person differently, other side effects may occur. Before use, we recommend discussing possible side effects with a healthcare provider who knows your medical history. You may also report side effects to your local poison control center or call the FDA at 1-800-FDA-1088.

7. Ascorbic Acid (VC)

Type: Topical Medication

Used to treat: Hyperpigmentation, sun-damaged skin, acne, wrinkles, and fine lines

How it works: Ascorbic acid acts as a reducing agent in multiple cellular chemical reactions, improving overall skin cell health and skin appearance.

Brief Description

Ascorbic acid (Vitamin C) is a potent antioxidant involved in multiple cellular functions. As an antioxidant, it acts as a reducing agent that fights free radicals in the body. As such, ascorbic acid is considered an essential detoxifying agent in the body. Ascorbic acid also has antibacterial properties, helping fight infections in the body. When used as a topical application, ascorbic acid also encourages collagen formation, leading to firmer and better-contoured skin.

Scientific Studies

Side Effects

Ascorbic acid has an excellent safety profile. Most people who use ascorbic acid topical applications experience no side effects. Those with hypersensitive skin may experience some mild irritation, which goes away as the skin adjusts to the regular application of the medication.

Mild side-effects are normal and mean the medication is working. Our doctors are always on hand to monitor your progress, track any side effects and assist with any questions you may have.

This is not a complete list of side effects. Since drugs affect each person differently, other side effects may occur. Before use, we recommend discussing possible side effects with a healthcare provider who knows your medical history. You may also report side effects to your local poison control center or call the FDA at 1-800-FDA-1088.

8. Ferulic Acid (FA)

Type: Topical Medication

Used to treat: Loose skin, fine lines, wrinkles, and age spots

How it works: Ferulic acid acts as a reducing agent within skin cells, fighting free radicals to give the skin a smoother, firmer, and healthier look.

Brief Description

Ferulic acid is a naturally occurring compound found in plants. Some of these plants include bran, rice, oats, citrus, apple seeds, and eggplant. Ferulic acid is a powerful antioxidant agent, making it an excellent anti aging compound. When used in a topical application, ferulic acid reduces the harmful effects that free radicals have on skin cells. When applied regularly, ferulic acid has been found to boost cellular health resulting in firmer, better-contoured skin with fewer wrinkles, lines, and age spots.

Scientific Studies

Side Effects

Ferulic acid has rare and mild side effects. However, since ferulic acid is extracted from different sources, this may cause an allergic reaction if you are allergic to the source item. For example, if you are allergic to bran, using ferulic acid extracted from bran may cause an allergic reaction.

Mild side-effects are normal and mean the medication is working. Our doctors are always on hand to monitor your progress, track any side effects and assist with any questions you may have.

This is not a complete list of side effects. Since drugs affect each person differently, other side effects may occur. Before use, we recommend discussing possible side effects with a healthcare provider who knows your medical history. You may also report side effects to your local poison control center or call the FDA at 1-800-FDA-1088.

9. Tretinoin

Type: Topical Medication

Used to treat: Fine lines, wrinkles, acne scars, and age spots

How it works: Tretinoin helps stimulate cell turnover on the skin. This action helps replace older skin cells with new cells, giving the skin an overall healthier, firmer appearance.

Brief Description

Tretinoin is a form of vitamin A or retinoid. As a retinoid, its primary action on the skin is to encourage cell turnover. When applied, it catalyzes the growth of new skin cells, helping replace older skin with new skin, faster. Tretinoin also has sebum (oil) regulation properties. It discourages excessive production of oil, helping the skin maintain a healthy balance. Tretinoin has anti-inflammatory properties too, helping clear up active inflammation symptoms like acne pustules.

Scientific Studies

Side Effects

Tretinoin has side effects which affect different people differently. Some may experience mild side effects while others may experience more severe side effects. Some common tretinoin side effects include burning or itching skin, unusual skin dryness, redness or skin peeling, skin that is warm to the touch and in some cases, skin lightening at the point of application.

This is not a complete list of side effects. Since drugs affect each person differently, other side effects may occur. Before use, we recommend discussing possible side effects with a healthcare provider who knows your medical history. You may also report side effects to your local poison control center or call the FDA at 1-800-FDA-1088.

10. Kojic Acid

Type: Topical Medication

Used to treat: Hyperpigmentation, dark spots caused by freckles, age spots, and melasma

How it works: Kojic acid inhibits tyrosine, an important agent in the formation of melanin. Disruption of melanin formation helps reduce dark patches and promote a more even overall skin tone.

Brief Description

Kojic acid is a naturally occurring substance used as a skin lightening agent in the cosmetic industry. As a bioactive agent, application of kojic acid helps disrupt the production of melanin, a skin darkening skin component. When applied regularly, new skin cells form with less melanin, potentially leading to a lighter complexion or the reduction of age spots. Kojic acid also has antifungal and antibacterial properties that help promote healthy skin by protecting the skin from harmful bacteria and skin funguses.

Scientific Studies

  • Study 4: Final Report of the Safety Assessment of Kojic Acid as Used in Cosmetics
    “The available human sensitization data supported the safety of kojic acid at a use concentration of 2% in leave-on cosmetics. The Cosmetic Ingredient Review (CIR) Expert Panel concluded that the 2 end points of concern, dermal sensitization and skin lightening, would not be seen at use concentrations below 1%; therefore, this ingredient is safe for use in cosmetic products up to that level.”

Side Effects

The most common kojic acid side effect is contact dermatitis that causes a rash, redness, itching, and skin dryness. In rare cases, pain and skin swelling may occur. Long-term use may also thin the skin, making it susceptible to sunburn.

This is not a complete list of side effects. Since drugs affect each person differently, other side effects may occur. Before use, we recommend discussing possible side effects with a healthcare provider who knows your medical history. You may also report side effects to your local poison control center or call the FDA at 1-800-FDA-1088.

Customized At-Home Treatments for Skin Hyperpigmentation

HYPERPIGMENTATION TREATMENT

Custom-Formulated Prescription Cream

One of our world-class dermatologists will formulate a custom prescription cream suited for your unique skin.

Whether you have dark spots, age spots, melasma, or post-inflammatory hyperpigmentation, ClearifiRx uses only the best ingredients in our custom formulations. Our carefully-sourced ingredients ensure the quality, safety, potency, and effectiveness of our creams.

Brandon Kirsch, MD
Brandon Kirsch
brandon.kirsch@clearifirx.com

Brandon Kirsch, MD, FAAD, is a board-certified dermatologist specializing in clinical drug development and medical innovation. He is the founder of Kirsch Dermatology in Naples, Florida (www.KirschDerm.com) and is also the Chief of Dermatology at the Naples Community Hospital.

Dr. Kirsch started his career as a lawyer and holds law degrees from the University of Western Ontario (LL.B.) and Georgetown (LL.M. Securities and Financial Regulation). Dr. Kirsch completed his pre-medical studies at the University of Pennsylvania, medical school at Brown University, internship at the Mayo Clinic (Florida) and dermatology residency at the University of North Carolina. In partnership with the Mayo Clinic, he filed to patent a novel topical composition for the treatment of skin hyperpigmentation that he co-developed and also oversaw a successful pilot study of the formulation.

Dr. Kirsch has experience with therapeutic drug development programs from pre-clinical to Phase 3 studies. He is licensed to practice medicine in California, Colorado, Florida, and North Carolina and law in New York and Ontario.



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