Can Oral Tranexamic Acid And Chemical Peels Be Used Together?

Can Oral Tranexamic Acid And Chemical Peels Be Used Together?

Topical skin care therapies typically combine multiple ingredients to deliver more impactful results. For example, a dermatologist might combine retinol with hyaluronic acid, ceramides, and SPF to balance out the benefits and drawbacks of each ingredient. Oral tranexamic acid and chemical peels work well independently, helping clear the skin of spots and dark patches. However, when combined, their benefits and drawbacks can influence the results.

Before using oral tranexamic acid and chemical peels together, it is vital to know whether combination treatment is safe and if the results will be better than if you used only one.

Oral tranexamic acid uses

Dermatologists prescribe oral tranexamic acid to treat melasma and other hyperpigmentation conditions. Studies have shown it can effectively lower the MASI (Melasma Area and Severity Index) score by up to 69% when taken consistently for eight to twelve weeks (Tan).

As an oral medication, it works as an effective adjuvant to topical treatments like hydroquinone, hyaluronic acid, and retinol. However, due to its action on cellular processes within the dermis, extra caution should be exercised when using it with some types of chemical peels that also target the dermis.

Chemical peel uses

During a chemical peel, a skin surgeon or dermatologist applies a chemical solution like salicylic acid, glycolic acid, or trichloroacetic acid to the skin (Soleymani). After some time, the skin blisters and exfoliates (peels), giving way to a smoother, healthier, and less damaged layer of skin beneath.

Chemical peels can be superficial, medium, or deep, depending on how far they penetrate into the skin. Superficial peels target only the epidermis (outer layer of the skin), while medium and deep ones target the dermis (the layer beneath the epidermis).

While superficial chemical peels can be used with other treatments, more caution is needed when considering medium and deep chemical peels.

Should You Use Oral Tranexamic Acid And Chemical Peels Together?

Oral tranexamic acid and deep chemical peels target the same layer of the skin, the dermis. Although scientists know how each treatment works, they do not yet fully understand their full impact on the skin. As such, it is vital to speak with a skin specialist such as the board-certified dermatologists at ClearifiRx to get a professional evaluation before using them together.

During your evaluation, one of our dermatologists will assess your skin, general health, and any other medication you are taking (e.g., acne medication). Using this data, they will give you the correct course of treatment that will offer maximum benefits while avoiding possible flare ups.

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Brandon Kirsch

Brandon Kirsch, MD, FAAD, is a board-certified dermatologist specializing in clinical drug development and medical innovation. He is the founder of Kirsch Dermatology in Naples, Florida ( and is also the Chief of Dermatology at the Naples Community Hospital.

Dr. Kirsch started his career as a lawyer and holds law degrees from the University of Western Ontario (LL.B.) and Georgetown (LL.M. Securities and Financial Regulation). Dr. Kirsch completed his pre-medical studies at the University of Pennsylvania, medical school at Brown University, internship at the Mayo Clinic (Florida) and dermatology residency at the University of North Carolina. In partnership with the Mayo Clinic, he filed to patent a novel topical composition for the treatment of skin hyperpigmentation that he co-developed and also oversaw a successful pilot study of the formulation.

Dr. Kirsch has experience with therapeutic drug development programs from pre-clinical to Phase 3 studies. He is licensed to practice medicine in California, Colorado, Florida, and North Carolina and law in New York and Ontario.

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